Preclinical models for pulmonary disease and drug delivery
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Ryan GM, Bischof RJ, Enkhbaatar P, McLeod VM, Chan LJ, Jones SA, Owen DJ, Porter CJH & Kaminskas LM (2016). A Comparison of the pharmacokinetics and pulmonary lymphatic exposure of a generation 4 PEGylated dendrimer following intravenous and aerosol administration to rats and sheep. Pharm Res 33: 510Download – PK studies: pulmonary drug delivery

Liravi B, Piedrafita D, Nguyen G & Bischof RJ (2015). Dynamics of IL-4 and IL-13 expression in the airways of sheep following allergen challenge. BMC Pulmonary Medicine 15:101; Download – Sheep Allergic Asthma Model: TH2 cytokines

Rajapaksa A, Ho J, Qi A, Bischof RJ, Nguyen T-H, Tate M, Piedrafita D, McIntosh M, Yeo L, Meeusen EN, Coppel R, & Friend J (2014). Effective aerosolized delivery of a plasmid DNA vaccine using a novel surface acoustic wave nebulizer. Respiratory Research 15: 60; Download – Airway DNA vaccine

Organ L, et al., (2014). A novel segmental challenge model for bleomycin-induced pulmonary fibrosis in sheep. Exp Lung Research: doi:10.3109/01902148.2014.985806; Download – Pulmonary Fibrosis

Meeusen ENT, Snibson KJ, Hirst SJ, & Bischof RJ (2010). Sheep as a model for the study and treatment of human asthma and other respiratory diseases. Drug Discovery Today: Disease Models 6: 101-106; Download - SheepModels

Snibson KJ, Bischof, RJ, Slocombe, RF & Meeusen EN (2005). Airway remodeling and inflammation in sheep lungs after chronic airway challenge with house dust mite. Clinical and Experimental Allergy 35: 146-152; Downloads - Sheep Chronic Asthma ModelEditorial-Models&Supermodels

Bischof RJ, Snibson K & Meeusen ENT (2003). Induction of allergic inflammation in the lungs of sensitized sheep after local challenge with house dust miteClinical and Experimental Allergy 33: 367-375Downloads - Sheep Allergic Asthma ModelEditorial-Comparative&Complimentary